• Resúmenes - - - - - - - - - - - - - - - - - Instituto de Parasitología y Biomedicina "López-Neyra" CSIC - - - - - - - - - - - - - - - - - - - -
    • Fotos Jornadas 2012
    • Jose M Rodríguez-Vargas - LAB105
    • Cristina Romero López - LAB112
    • Maria Morell - LAB202
    • Jenny Campos-Salinas - LAB213
    • Paula M. Sánchez Carrasco - 103/104
    • Francisco Macías Huete - LAB212
    • Michael Caraballo - LAB210
    • Beatriz del Blanco - LAB110
    • Juan Pablo Muñoz-Cobo Belart - LAB109
    • Diana Lopez-Farfan - LAB102
    • Perandrés López, Rubén - LAB209
    • Samuel Prieto Vega - LAB111
    • Agustina Arias - LAB211

Beatriz del Blanco - LAB110

Tcra ENHANCER ACTIVITY DURING αβ T-­cell DEVELOPMENT

The generation of αβ T-lymphocytes requires the construction of a T-cell receptor (TCR) complex through a highly ordered series of somatic rearrangement events at the Tcra and Tcrb loci during thymocyte development. Tcra enhancer (Eα) is essential for activation of germline transcription and VαJα gene segment recombination at the Tcra locus during thymocyte development. This enhancer influences chromatin structure across a 5OO-kb region in the Tcra locus. 

My project is focused on the molecular mechanisms for Eα function during the development of αβ T-lymphocytes. My data indicate that binding of inducible transcription factors to an Eα enhanceosome previously assembled through the binding of constitutive and lymphoid specific-factors activates enhancer function during thymocyte development. Thus, the combinatorial assembly of tissue-and signal-specific transcription factors dictates Eα function in thymocytes. My current research  tries to understand Eα function during  development of αβ T-lymphocytes using different animal models to investigate whether Eα function is restricted to immature T-cells.