LINEAS DE INVESTIGACIÓN

ORGANISMOS FINANCIADORES ÚLTIMOS 5 AÑOS

- LRRK2 Biology Consortium Program "LRRK2-mediated centrosomal cohesion alterations". PROYECTO, , Ref: MMF_2018, (2018 - 2021).

- RELACION ENTRE LRRK2 Y EL DEFICIT DE TRAFICO VESICULAR MEDIADO POR RABS EN LA ENFERMEDAD DE PARKINSON. PROYECTO, PN2017 - PROY I+D+I - PRG. RETOS DE LA SOCIEDAD, Ref: SAF2017-89402-R, (2018 - 2020).

- Kinase-activity-mediated centrosomal alterations in LRRK2-PD and sporadic PD-patient-derived cells and link to altered Rab protein-locaization/Phosphorylation. PROYECTO, Michael J. Fox Foundation for Parkinson`s Research 2017, Ref: MJFF_2017, (2017 - 2018).

- LRRK2-mediated endolysosomal alterations:mechanistic insights and validation as pharmacodynamic readout for kinase inhibitor studies. PROYECTO, , Ref: MJFF_2016, (2016 - 2018).

- PS-derived neural presucros cells to study mechanisms and identify modulators of Parkinson¿s disease.. PROYECTO, F. BBVA-AYUDAS A PROYECTOS DE INVESTIGACIÓN 2014, Ref: 201422031, (2014 - 2018).

PUBLICACIONES ÚLTIMOS 5 AÑOS

-Fernández, B.; Olmedo, P.; Gil, F.; Fdez, E.; Naaldijk, Y.; Rivero-Ríos, P.; Bracher, F.; Grimm, C.; Churchill, G.C.; Hilfiker, S., Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB, Cell Death & Disease, 2022, Vol. 13: 12-1047, ARTÍCULO, Id:920154

-Antonio Jesús Lara Ordóñez; Rachel Fasiczka; Belén Fernández; Yahaira Naaldijk; Elena Fdez; Marian Blanca Ramírez; Sébastien Phan; Daniela Boassa; Sabine Hilfiker, The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization, Biology Open, 2022, Vol. 11: 8-bio059468, ARTÍCULO, Id:894526

-Fdez, E; Madero-Pérez, J; Lara Ordóñez, A.J; Naaldijk, Y; Fasiczka, R; Aiastui, A; Ruiz Martínez, J; López de Munain, A; Cowley, S.A; Wade-Martins, R; Hilfiker, S, Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement, iScience, 2022, Vol. 25: 1044766-104476, ARTÍCULO, Id:892848

-Fernández, B; Chittoor-Vinod, V.G; Kluss, J.H; Kelly, K; Bryant, N; Nguyen, A.P.T; Bukhari, S.A; Smith, N; Lara Ordóñez, A.J; Fdez, E; Chartier-Harlin, M.C; Montine, T.J; Wilson, M.A; Moore, D.J; West, A.B; Cookson, M.R; Nichols, R.J; Hilfiker, S, Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity, Journal of Parkinsons Disease, 2022, Vol. 12: 1423-1447, ARTÍCULO, Id:892847

-Ordóñez, A.J.L.; Fasiczka, R.; Naaldijk, Y.; Hilfiker, S., Rab GTPases in Parkinson’s disease: a primer, Essays in Biochemistry, 2021, Vol. 65: 961-974, ARTÍCULO DE REVISIÓN, Id:868210

-Rivero-Ríos, P.; Romo-Lozano, M.; Fernández, B.; Fdez, E.; Hilfiker, S., Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations, Cells, 2020, Vol. 9: , ARTÍCULO, Id:812239

-Rivero-Ríos, P.; Romo-Lozano, M.; Fasiczka, R.; Naaldijk, Y.; Hilfiker, S., LRRK2-Related Parkinson’s Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis, Frontiers in Neuroscience, 2020, Vol. 14: 556, ARTÍCULO DE REVISIÓN, Id:809748

-Lara Ordónez, A.J.; Fernández, B.; Fdez, E.; Romo-Lozano, M.; Madero-Pérez, J.; Lobbestael, E.; Baekelandt, V.; Aiastui, A.; López de Munaín, A.; Melrose, H.L.; Civiero, L.; Hilfiker, S., RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits, Human Molecular Genetics, 2019, Vol. 28: 3552-3568, ARTÍCULO, Id:781631

-Rivero-Ríos, P.; Romo-Lozano, M.; Madero-Pérez, J.; Thomas, A.P.; Biosa, A.; Greggio, E.; Hilfiker, S., The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A, Journal of Biological Chemistry, 2019, Vol. 294: 4738-4758, ARTÍCULO, Id:748045

-Madero-Pérez, J.; Fernández, B.; Lara Ordóñez, A.J.; Fdez, E.; Lobbestael, E.; Baekelandt, V.; Hilfiker, S., RAB7L1-mediated relocalization of LRRK2 to the golgi complex causes centrosomal deficits via RAB8A, Frontiers in Molecular Neuroscience, 2018, Vol. 11: 417, ARTÍCULO, Id:735371

-Madero-Pérez, J.; Fdez, E.; Fernández, B.; Lara Ordóñez, A.J.; Blanca Ramírez, M.; Gómez-Suaga, P.; Waschbüsch, D.; Lobbestael, E.; Baekelandt, V.; Nairn, A.C.; Ruiz-Martínez, J.; Aiastui, A.; López De Munain, A.; Lis, P.; Comptdaer, T.; Taymans, J.M.; Chartier-Harlin, M.C.; Beilina, A.; Gonnelli, A.; Cookson, M.R.; Greggio, E.; Hilfiker, S., Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation, Molecular Neurodegeneration, 2018, Vol. 13: 1-3, ARTÍCULO, Id:715230

TESIS DOCTORALES ÚLTIMOS 5 AÑOS