LINEAS DE INVESTIGACIÓN

ORGANISMOS FINANCIADORES ÚLTIMOS 5 AÑOS

PUBLICACIONES ÚLTIMOS 5 AÑOS

-Guzmán-Carrasco, A.; Kapravelou, G.; López-Jurado, M.; Bermúdez, F.; Andrés-León, E.; Terrón-Camero, L.C.; Prados, J.; Melguizo, C.; Porres, J.M.; Martínez, R., A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model, Antioxidants, 2024, Vol. 13: 3-274, ARTÍCULO, Id:998929

-Anis Barmada; Louis-François Handfield; Gerard Godoy-Tena; Carlos Calle-Fabregat; Laura Ciudad; Anna Arutyunyan; Eduardo Andrés-León; Regina Hoo; Tarryn Porter; Agnes Oszlanczi; Laura Richardson; Fernando J. Calero-Nieto; Nicola K. Wilson; Domenica Marchese; Carmen Sancho-Serra; Jorge Carrillo; Silvia Presas-Rodríguez; Cristina Ramo-Tello; Adolfo Ruiz-Sanmartin; Ricard Ferrer; Juan Carlos Ruiz-Rodriguez; Mónica Martínez-Gallo; Mónica Munera-Campos; Jose Manuel Carrascosa; Berthold Göttgens; Holger Heyn; Elena Prigmore; Ivette Casafont-Solé; Xavier Solanich; Ildefonso Sánchez-Cerrillo; Isidoro González-Álvaro; Maria Gabriella Raimondo; Andreas Ramming; Javier Martin; Eva Martínez-Cáceres; Esteban Ballestar; Roser Vento-Tormo; Javier Rodríguez-Ubreva, Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection, European Journal of Immunology, 2024, Vol. 54: 11-2350633, ARTÍCULO, Id:968605

-Lucia Chica-Redecillas; Sergio Cuenca-Lopez; Eduardo Andres-Leon; Laura Carmen Terron-Camero; Blanca Cano-Gutierrez; Jose Manuel Cozar; Jose Antonio Lorente; Fernando Vazquez-Alonso; Luis Javier Martinez-Gonzalez; Maria Jesus Alvarez-Cubero, Multi-omic study to unmask genes involved in prostate cancer development in a multi-case family, Cancer Communications, 2024, Vol. 44: 443-447, CARTA AL EDITOR, Id:968159

-Gonzalo Borrego-Yaniz; Laura C. Terrón-Camero; Martin Kerick; Eduardo Andrés-León; Javier Martin, A holistic approach to understanding immune-mediated inflammatory diseases: bioinformatic tools to integrate omics data, Computational and Structural Biotechnology Journal, 2024, Vol. 23: 96-105, ARTÍCULO, Id:968158

-Perurena-Prieto, J.; Sanz-Martínez, M.T.; Viñas-Giménez, L.; Codina-Clavaguera, C.; Triginer, L.; Gordillo-González, F.; Andrés-León, E.; Batlle-Masó, L.; Martin, J.; Selva-O'Callaghan, A.; Pujol, R.; McHugh, N.J.; Tansley, S.L.; Colobran, R.; Guillen-Del-Castillo, A.; Simeón-Aznar, C.P., Expanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing, Journal of Autoimmunity, 2024, Vol. 149: 103328, ARTÍCULO, Id:1018357

-Estupiñán-Moreno, E.; Hernández-Rodríguez, J.; Li, T.; Ciudad, L.; Andrés-León, E.; Terron-Camero, L.C.; Prieto-González, S.; Espígol-Frigolé, G.; Cid, M.C.; Márquez, A.; Martin, J.; Ballestar, E.; Ortiz-Fernández, L., Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes, Journal of Autoimmunity, 2024, Vol. 146: 103240, ARTÍCULO, Id:1005336

-Eduardo Salas-Espejo; Laura C. Terrón-Camero¿; José L. Ruiz; Nerea M. Molina; Eduardo Andrés-León¿, Exploring the microbiome in human reproductive tract: high-throughput methods for the taxonomic characterization of microorganisms, Seminars in Reproductive Medicine, 2023, Vol. 41: 125-143, ARTÍCULO DE REVISIÓN, Id:968160

-Castillo-González, J.; Ruiz, J.L.; Serrano-Martínez, I.; Forte-Lago, I.; Ubago-Rodriguez, A.; Caro, M.; Pérez-Gómez, J.M.; Benítez-Troncoso, A.; Andrés-León, E.; Sánchez-Navarro, M.; Luque, R.M.; González-Rey, E., Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity, Journal of Neuroinflammation, 2023, Vol. 20: 1-226, ARTÍCULO, Id:963062

-Ramírez-Mena, A.; Andrés-León, E.; Alvarez-Cubero, M.J.; Anguita-Ruiz, A.; Martinez-Gonzalez, L.J.; Alcala-Fdez, J., Explainable artificial intelligence to predict and identify prostate cancer tissue by gene expression, Computer Methods and Programs in Biomedicine, 2023, Vol. 240: 107719, ARTÍCULO, Id:954814

-Medina-Carmona, E.; Gutierrez-Rus, L.I.; Manssour-Triedo, F.; Newton, M.S.; Gamiz-Arco, G.; Mota, A.J.; Reiné, P.; Cuerva, J.M.; Ortega-Muñoz, M.; Andrés-León, E.; Ortega-Roldan, J.L.; Seelig, B.; Ibarra-Molero, B.; Sanchez-Ruiz, J.M., Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate, Molecular Biology and Evolution, 2023, Vol. 40: 3-msad032, ARTÍCULO, Id:953661

-Eduardo Andres Leon; Ana Rojas, Identification of novel microRNAs associated with type 2 diabetes by an integrative bioinformatic analysis, Human Gene, 2022, Vol. 34: 1-201125, ARTÍCULO, Id:908155

-Laura C. Terrón-Camero; Fernando Gordillo-González; Eduardo Salas-Espejo; Eduardo Andrés-León, Comparison of Metagenomics and Metatranscriptomics Tools: A Guide to Making the Right Choice, GENES, 2022, Vol. 13: 2280-2280, ARTÍCULO, Id:908154

-García-Hernández, R.; Perea-Martínez, A.; Manzano, J.I.; Terrón-Camero, L.C.; Andrés-León, E.; Gamarro, F., Transcriptome Analysis of Intracellular Amastigotes of Clinical Leishmania infantum Lines from Therapeutic Failure Patients after Infection of Human Macrophages, Microorganisms, 2022, Vol. 10: 7-1304, ARTÍCULO, Id:901810

-Tiana, M.; Lopez-Jimenez, E.; de Aja, J.S.; Barral, A.; Victorino, J.; Badia-Careaga, C.; Rollan, I.; Rouco, R.; Santos, E.; Sanchez-Iranzo, H.; Acemel, R.D.; Torroja, C.; Adan, J.; Andres-Leon, E.; Gomez-Skarmeta, J.L.; Giovinazzo, G.; Sanchez-Cabo, F.; Manzanares, M., Pluripotency factors regulate the onset of Hox cluster activation in the early embryo, Science Advances, 2022, Vol. 8: 28-eabo3583, ARTÍCULO, Id:900530

-Elkyn Estupiñán-Moreno; Lourdes Ortiz-Fernández; Tianlu Li  3; Jose Hernández-Rodríguez; Laura Ciudad; Eduardo Andrés-León; Laura Carmen Terron-Camero; Sergio Prieto-González; Georgina Espígol-Frigolé; Maria Cinta Cid; Ana Márquez; Esteban Ballesta; Javier Martín, Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids, Annals of the Rheumatic Diseases, 2022, Vol. 81: 1290-1300, ARTÍCULO, Id:900132

-Francisco R. Marin; Eduardo Andrés-León; Alberto Dávalos; Dylan Kiltschewskij; Maria C. Crespo; Murray Cairns; Cristina Soler-Rivas, RNA-Seq, Bioinformatic Identification of Potential MicroRNA-like Small RNAs in the Edible Mushroom Agaricus bisporus and Experimental Approach for Their Validation, International Journal of Molecular Sciences, 2022, Vol. 23: 19-4923, ARTÍCULO, Id:888873

-Raquel Benitez; Marta Caro; Eduardo Andres-Leon; Francisco O'Valle; Mario Delgado, Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic¿and cholestatic¿induced liver injury, British Journal of Pharmacology, 2022, Vol. 179: 2275-2296, ARTÍCULO, Id:888782

-María Dolores Molina-Sánchez; Fernando Manuel García-Rodríguez; Eduardo Andrés-León; Nicolás Toro, Identification of Group II Intron RmInt1 Binding Sites in a Bacterial Genome, Frontiers in Molecular Bioscience, 2022, Vol. 9: 1-834020, ARTÍCULO, Id:888781

-Teresa Maria Linares-Pineda; Hatim Boughanem; Carolina Gutiérrez-Repiso; Manuel Macías-González; Eduardo Andrés-León; Gemma Rojo-Martínez; Sergio Valdés; Francisco J. Tinahones; Sonsoles Morcillo, Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study, European Journal of Clinical Investigation, 2022, Vol. 52: 18-e13783, ARTÍCULO, Id:888780

-Daniel J. García-Domínguez; Nabil Hajji; Roser López-Alemany; Sara Sánchez-Molina; Elisabet Figuerola-Bou; Francisco J. Morón Civanto; Santiago Rello-Varona; Eduardo Andrés-León; Adrián Benito; Hector C. Keun; Jaume Mora; Óscar M. Tirado; Enrique de Álava; Lourdes Hontecillas-Prieto, Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1, Oncogene, 2022, Vol. 41: 2638-2650, ARTÍCULO, Id:888777

-Javier Rodríguez-Ubreva; Anna Arutyunyan; Marc Jan Bonder; Lucía Del Pino-Molina; Stephen J. Clark; Carlos de la Calle-Fabregat; Luz Garcia-Alonso; Louis-François Handfield; Laura Ciudad; Eduardo Andrés-León; Felix Krueger; Francesc Català-Moll; Virginia C. Rodríguez-Cortez; Krzysztof Polanski; Lira Mamanova; Stijn van Dongen; Vladimir Yu. Kiselev; María T. Martínez-Saavedra; Holger Heyn; Javier Martín; Klaus Warnatz; Eduardo López-Granados; Carlos Rodríguez-Gallego; Oliver Stegle; Gavin Kelsey; Roser Vento-Tormo; Esteban Ballestar, Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses, Nature Communications, 2022, Vol. 13: 11-1779, ARTÍCULO, Id:888776

-Rodríguez-Caparrós, A.; Álvarez-Santiago, J.; López-Castellanos, L.; Ruiz-Rodríguez, C.; Valle-Pastor, M.J.; López-Ros, J.; Angulo, Ú.; Andrés-León, E.; Suñé, C.; Hernández-Munain, C., Differently Regulated Gene-Specific Activity of Enhancers Located at the Boundary of Subtopologically Associated Domains: TCRα Enhancer, Journal of Immunology, 2022, Vol. 208: 910-928, ARTÍCULO, Id:888147

-José Ignacio Manzan; Ana Perea-Martínez; Raquel García-Hernández; Eduardo Andrés-León; Laura C. Terrón-Camero; José Antonio Poveda; Francisco Gamarro, Modulation of cholesterol pathways in clinical isolates of Leishmania infantum-Infected Human Macrophages., Frontiers in cellular and infection microbiology, 2022, Vol. 12: 878711-878711, ARTÍCULO, Id:887851

-Antonio Alcina; Maria Fedetz; Isabel Vidal-Cobo; Eduardo Andrés-León; Maria-Isabel García-Sánchez; Alicia Barroso-Del-Jesus; Sara Eichau; Elia Gil-Varea; Luisa-Maria Villar; Albert Saiz; Laura Leyva; Koen Vandenbroeck; David Otaegui; Guillermo Izquierdo; Manuel Comabella; Elena Urcelay; Fuencisla Matesanz, Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis, Human Molecular Genetics, 2022, Vol. 31: 2155-2163, ARTÍCULO, Id:887580

-Desiré Casares-Marfil; Martin Kerick; Eduardo Andrés-León; Pau Bosch-Nicolau; Israel Molina; Chagas Genetics CYTED Network; Javier Martin; Marialbert Acosta-Herrera, GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels, PLoS Neglected Tropical Diseases, 2021, Vol. 15: 9874-e0009874, ARTÍCULO, Id:856180

-Martínez-Blanco, A.; Domínguez-Pantoja, M.; Botía-Sánchez, M.; Pérez-Cabrera, S.; Bello-Iglesias, N.; Carrillo-Rodríguez, P.; Martin-Morales, N.; Lario-Simón, A.; Pérez-Sánchez-Cañete, M.M.; Montosa-Hidalgo, L.; Guerrero-Fernández, S.; Longobardo-Polanco, V.M.; Redondo-Sánchez, S.; Cornet-Gomez, A.; Torres-Sáez, M.; Fernández-Ibáñez, A.; Terrón-Camero, L.; Andrés-León, E.; O¿Valle, F.; Merino, R.; Zubiaur, M.; Sancho, J., CD38 Deficiency Ameliorates Chronic Graft-Versus-Host Disease Murine Lupus via a B-Cell-Dependent Mechanism, Frontiers in Immunology, 2021, Vol. 12: 713697, ARTÍCULO, Id:854129

-Daniel J. García-Domínguez; Nabil Hajji; Sara Sánchez-Molina3; Elisabet Figuerola-Bou; Rocío M. de Pablos; Ana M. Espinosa-Oliva; Eduardo Andrés-León; Laura Carmen Terrón-Camero; Rocío Flores-Campos; Guillem Pascual-Pasto; María José Robles; Isidro Machado; Antonio Llombart-Bosch; Giovanna Magagnoli; Katia Scotlandi; Ángel M. Carcaboso; Jaume Mora; Enrique de Álava; Lourdes Hontecillas-Prieto, Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma, Oncogene, 2021, Vol. 40: 5843-, ARTÍCULO, Id:843325

-Elena López-Jiménez; Eduardo Andrés-León, The Implications of ncRNAs in the Development of Human Diseases, Non-coding RNA, 2021, Vol. 7: 171-17, ARTÍCULO DE REVISIÓN, Id:843295

-Alberto Sola-Leyva; Eduardo Andrés-León; Nerea M. Molina; Laura Carmen Terron-Camero; Julio Plaza-Díaz; María Jose ¿ Saéz-Lara; María Carmen Gonzalvo; Rocío Sánchez; Susana Ruíz; Luís Martínez; Signe Altmae, Mapping the entire functionally active endometrial microbiota, Human Reproduction, 2021, Vol. 36: 1021-1031, ARTÍCULO, Id:843294

-Raquel Luzon-Hidalgo; Valeria A. Risso; Asuncion Delgado; Eduardo Andrés-León; Beatriz Ibarra-Molero; Jose M. Sanchez-Ruiz, Evidence for a role of phenotypic mutations in virus adaptation, iScience, 2021, Vol. 24: 1022574-102257, ARTÍCULO, Id:843293

-Luis Javier Martínez-González; Victor Sánchez-Conde; Jose María González-Cabezuelo; Alba Antunez-Rodríguez; Eduardo Andrés-León; Inmaculada Robles-Fernandez; Jose Antonio Lorente; Fernando Vázquez-Alonso; María Jesus Alvarez-Cubero, Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer, Biomedicines, 2021, Vol. 9: 646-646, ARTÍCULO, Id:843292

-Mónica Fernández-Cortés; Eduardo Andrés-León; Francisco Javier Oliver, The PARP Inhibitor Olaparib Modulates the Transcriptional Regulatory Networks of Long Non-Coding RNAs during Vasculogenic Mimicry, Cells, 2020, Vol. 12: 26909-2690, ARTÍCULO, Id:820979

-Tianlu Li; Eduardo Andrés-León; Lourdes Ortiz-Fernández; Laura Ciudad; Biola M Javierre; Elena López-Isac; Alfredo Guillén-Del-Castillo; Carmen Pilar Simeón-Aznar; Esteban Ballestar; Javier Martin, Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci., Genome Medicine, 2020, Vol. 12: 11-81, ARTÍCULO, Id:814086

-García-Domínguez, D.J.; Hontecillas-Prieto, L.; Andrés León, E.; Sánchez-Molina, S.; Rodríguez-Núñez, P.; Morón, F.J.; Hajji, N.; Mackintosh, C.; de Álava, E., An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogenesis, PLoS ONE, 2020, Vol. 15: 6-e0234243, ARTÍCULO, Id:809497

TESIS DOCTORALES ÚLTIMOS 5 AÑOS