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Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA


Empar Vengut-Climent, Irene Gómez-Pinto, Ricardo Lucas, Pablo Peñalver, Anna Aviñó, Célia Fonseca Guerra, F. Matthias Bickelhaupt, Ramón Eritja, Carlos González, and Juan C. Morales*.

New lego pieces: The formation of a glucose–nucleobase pseudo base pair is proposed as a new type of biomolecular interaction. When formed within a DNA double helix the high-resolution structure shows only a minor distortion. These DNA duplexes are less stable than natural ones, but glucose shows preference for binding purine nucleobases. Moreover, quantum chemical calculations indicate that glucose–purine pairs are as stable as a natural T–A pair..

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Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA

 

Angewandte Chemie International Edition 2016, in press, DOI: 10.1002/anie.201603510

 

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